Ad-free rankings · 6 NAD+ brands independently reviewed
Updated April 2026
EnergyNAD+

Fuel your cells. Restore your energy.

NAD+ therapy from IV infusion to nasal spray — compare five clinics and at-home brands on delivery method, dosing frequency and real price per dose.

Brands
6compared
From
$60/mo
Delivery
IV · Inj. · Spray
87%
improved energy · 8 weeks
Independently compared · 6 providers reviewed
MAREK HEALTHRestoreAgelessRxLimitless Lifedrip.hydrationVerde
Personal to you

Find the right NAD+ protocol for your goals

Your delivery preference, dosing frequency and budget shape which provider is right for you. Tell us a little about what you're trying to achieve and we'll find the best match for you — all in under 2 minutes.

What's being prescribed

NAD+ delivery methods explained. What actually gets to your cells.

Nicotinamide Adenine Dinucleotide — NAD+ — can be delivered in four different ways. Bioavailability — the amount and speed with which the active ingredient reaches the bloodstream — cost and convenience vary enormously between them. Here's a summary of all four delivery methods.

At a glanceIV InfusionSubq InjectionNasal SprayOral NMN/NR
BioavailabilityHighestHighMidLower
Dosing frequencyMonthly or quarterly3–7× per week1–2× dailyDaily, ongoing
SettingClinic or mobileAt homeAt homeAt home
Starting price$200/session$60/month$40/month$30/month
Best forIntensive resetWeekly protocolsDaily maintenanceEntry / budget

← Swipe to compare all four methods →

IV NAD+ Infusion

Highest bioavailability · clinic-based
IV Drip
From$200/sessionDosingMonthly+SettingClinic
What is it?Intravenous infusion — administering NAD+ directly into the bloodstream via the user's vein. This will be delivered in a clinic, under medical supervision. Mobile IV therapy may be available in your location.
Ideal forIntensive reset or post-illness recovery.

How it works

IV NAD+ Infusion delivers Nicotinamide Adenine Dinucleotide directly into the bloodstream. This produces the highest and fastest rise in circulating NAD+ levels. A typical session can last 2–4 hours for a 500mg infusion or 4–6 hours for 1,000mg. Infusing too quickly causes a flushing/chest-tightening sensation, so slower infusion rates (over 2–3 hours) are preferred by most providers.

Typical dosing

Introductory: 250–500mg infusion, with 1–2 sessions. This typically followed by maintenance dosing of 500–1,000mg per session, which can be monthly or quarterly.

Price range

$200–$450 per 500mg session, or $350–$700 per 1,000mg session, delivered in a clinic setting. Price for Mobile NAD+ IV infusion may be higher.

Key considerations

As IV NAD+ Infusion is delivered directly into the bloodstream it has the highest bioavailability of any delivery method. However, be aware that this method needs a clinic visit or a mobile appointment, so it's not suitable for routine weekly use. Also, users should understand that slow infusion is important. During the process, some people may experience nausea, chest tightness, or muscle cramps. These are all temporary symptoms.

Subcutaneous NAD+ Injection

At-home · prescribed by telehealth
Inject
From$60/monthDosing3–7×/weekSettingAt home
What is it?This is a self-administered subcutaneous injection — a subcutaneous injection is delivered into the layer of fat between the skin and muscle. This can be done at home, so it's a convenient option.
Ideal forOngoing weekly protocols, athletic recovery, lifestyle changes.

How it works

NAD+ is injected into the fatty tissue beneath the skin, and absorbed directly into the bloodstream without going through the digestive system (just like IV infusion). This means bioavailability is significantly higher than oral and comparable to IV, though peak levels are achieved more gradually. Syringes are small and injections are well-tolerated by most users.

Typical dosing

A typical dosage schedule is 50–100mg per injection, delivered 3–7 times per week.

Price range

$60–$200/month depending on dose and frequency.

Key considerations

This method is popular, as it offers high bioavailability from the comfort of your home, with small, easy-to-use insulin syringes. However, users have to be comfortable with self-injection.

NAD+ Nasal Spray

Daily · no needles
Nasal
From$40/monthDosingDailySettingAt home
What is it? Exactly as it sounds — NAD+ is delivered via a nasal spray. This can be done at home, and either obtained over the counter or prescribed.
Ideal forMaintenance dosing, daily cognitive support, entry-level protocol.

How it works

Nasal NAD+ is absorbed through the nasal mucosa and directly into the bloodstream. Bioavailability is higher than oral supplements but lower than injection methods. Most products deliver small doses (5–25mg per spray) and are designed for daily or twice-daily use.

Typical dosing

1–2 sprays per nostril, once or twice daily. This is the equivalent to approximately 5–25mg NAD+ per dose.

Price range

$40–$120/month.

Key considerations

With no injection required, this can be a good option for users who don't like needles. It absorbs faster than oral supplements and has a lower dose per application than injection or IV — making it better suited to maintenance rather than intensive protocols.

Oral NMN / NR Supplements

Precursor supplements · no Rx
Oral
From$30/monthDosingDailySettingAt home
What is it? Oral supplements using NAD+ precursors — Nicotinamide Mononucleotide (NMN) or Nicotinamide Riboside (NR). No prescription is needed and these can be taken at home.
Ideal forGeneral preventive health, first-time NAD+ users, budget-conscious users.

How it works

Oral supplements don't deliver NAD+ directly. Instead, they deliver precursor molecules (NMN or NR) that the body converts to NAD+ inside cells. Bioavailability is lower than injectable, IV and nasal spray options and a significant proportion is broken down in the digestive tract. However, multiple peer-reviewed studies show oral NMN and NR do meaningfully raise intracellular NAD+ levels at doses of 250–500mg/day.

Typical dosing

NMN: 250–500mg/day (often morning, with water). NR: 300–600mg/day. Typically taken for 4–8 weeks to assess effect.

Price range

$30–$80/month (quality varies significantly by brand).

Key considerations

Requiring no injection, prescription, or clinic visit, this is the lowest barrier entry point. While bioavailability is lower than other routes, measurable NAD+ boost has been confirmed in blood tests.

Why NAD+ matters

Your cells run on it. Production declines with age.

NAD+ (Nicotinamide Adenine Dinucleotide) is the molecule your mitochondria use to convert food into energy.

~50%

By the age of 50, NAD+ levels are roughly half of what they were compared to 20 years of age.

NAD+ levels by age
~50%100%75%50%25%2030405060Age

Understand your baseline

A brief health intake assesses your fatigue patterns, sleep quality, supplement history and goals — whether that's cognitive performance, recovery, or anti-aging. The delivery method is matched to your lifestyle.

Choose your delivery

IV drip delivers the fastest and most potent systemic effect. Subcutaneous injection is the at-home equivalent. Nasal spray and oral NMN/NR are the gentlest entry points — no needles, no clinic.

Stack or start simple

Most providers offer NAD+ standalone. Premium plans layer in Vitamin C, glutathione, methylation support (TMG), or peptides.

What to expect

How NAD+ gets to work

Timelines vary by delivery method. Here's what most users notice — and when — across the four routes.

  1. 24–48 hours

    IV NAD+ users often feel a noticeable lift in energy and mental clarity within the first day or two of an infusion.

  2. Week 1–2

    Injection-protocol users typically report improved energy and focus by the end of the second week of consistent dosing.

  3. Week 4–6

    Oral NMN/NR users start to see subjective effects emerge as bioavailability builds with consistent daily dosing.

  4. Week 8 and beyond

    Most users report meaningful, sustained energy and recovery improvements across all methods. Long-term effects on cellular ageing remain an active area of research.

Is this right for you?

Common reasons people start an NAD+ protocol

Chronic fatigue or low energy

Not fixed by improved sleep or diet and lifestyle changes. Mitochondrial NAD+ depletion is one of several drivers — often responsive to supplementation.

Post-COVID brain fog

NAD+ depletion is documented post-SARS-CoV-2 infection. IV and injectable protocols are increasingly used in long-COVID recovery, and other illness recovery.

Athletic recovery

Training-induced oxidative stress depletes NAD+. Higher availability accelerates muscle repair and reduces inflammation markers.

Age-related decline (40+)

NAD+ levels decline roughly 50% between ages 20 and 60. Therefore, supplementation from the age of 40 onward can be recommended as a preventive measure.

Cognitive performance

NAD+ supports the sirtuins — a family of proteins that regulate gene expression, DNA repair and stress response.

Mood and sleep quality

NAD+ influences serotonin synthesis and circadian rhythm regulation. Some users report improved sleep depth alongside energy benefits.

Anti-aging / longevity

David Sinclair's research at Harvard has brought NAD+ into mainstream longevity science. While no human immortality studies exist, the mechanistic evidence for cellular ageing pathways is strong.

Supplement stacking

Interested in building a full longevity stack? NAD+ pairs well with resveratrol, TMG, and peptides. Some providers bundle these explicitly.

A note on safetyNAD+ therapy is generally well-tolerated and does not require a prescription for oral NMN/NR supplements. Injectable and IV forms are prescribed through a telehealth or clinic intake. Consult a clinician if you have active cancer as some oncology teams advise caution around NAD+ precursors.
Real results

What patients actually say after starting NAD+

“

I'd had brain fog and exhaustion since COVID in 2022. Three sessions of IV NAD+ at Restore and I felt genuinely different — sharper, less flat. I'm now on a monthly injectable protocol through Marek.

TW
Tom W, 44
Marek Health / Restore
“

I was sceptical — it sounds like a wellness fad. But I'm 51 and my energy has been genuinely better since I started AgelessRx's injection protocol six weeks ago. I have more data now thanks to their bloodwork.

KH
Karen H, 51
AgelessRx
“

I started with NMN capsules to test the water. Three months in I upgraded to subcutaneous injections through Limitless. The difference in recovery after training sessions is real.

JM
Jake M, 38
Limitless Life
Our process

We do the research. You make the call.

01

Answer 6 short questions

Tell us what you're trying to address, your delivery preference, and how often you're willing to dose. We use this to match you to the right protocol — not just the most popular one.

02

See your personalised shortlist

Up to five providers ranked by how well they match your goals and delivery preference — with real prices per session or per month, clearly displayed.

03

Compare, choose, and go

Pin up to three providers for a direct comparison, save your shortlist, and click through to start your intake. We surface the right provider — the rest is up to you.

Questions, answered

Honest answers to common questions

Research into the effectiveness of NAD+ is ongoing so the long-term benefits remain unknown. But, peer-reviewed studies in humans confirm that oral NMN and NR raise blood NAD+ levels with many users saying energy levels have improved, among other benefits.
NAD+ is the molecule your cells use. NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are precursors — the body converts them to NAD+ inside cells. IV or injectable NAD+ delivers the molecule directly; oral NMN/NR work indirectly via the salvage pathway. All three raise intracellular NAD+ levels, with different efficiency and cost profiles.
For an intensive reset, yes — IV delivers the highest and fastest peak. For ongoing maintenance, subcutaneous injection — when NAD+ is injected into the layer of fat between skin and muscle — is comparably effective and far more practical. Most practitioners will start patients with an IV loading phase and then switch to home injections for maintenance.
There can be, yes. IV NAD+ can cause temporary chest tightness, nausea, or muscle cramps if infused too quickly — all manageable by slowing the infusion rate and usually only temporary during the IV process. Subcutaneous injection site reactions are mild. Oral NMN/NR is generally very well-tolerated; occasional GI discomfort at high doses.
Generally yes, but inform your prescribing clinician of everything you're taking to be sure. NAD+ precursors can interact with certain chemotherapy agents — raise this if relevant. Some practitioners advise cycling NAD+ (5 days on / 2 off) rather than continuous dosing.
Get your match

Find your NAD+ protocol in 2 minutes

Answer a few short questions about your goals and delivery preference. We'll show you which providers match — with real prices per dose, no email required.